The association of Fer with the actin-organizing protein cortactin might help coordinate cellular response to various adhesive inputs. Cell-cell adhesion, Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion, Exposure of human vascular endothelial cells to sustained hydrostatic pressure stimulates proliferation. Adhesive interactions in differentiation and morphogenesis. PKC has numerous roles in promoting cell–cell and cell–matrix adhesions (Larsson, 2006). Reorganization of the actin cytoskeleton by cortactin can enhance either cell–cell adhesion or migration. It is known to activate integrins in various cell types, demonstrating a role for Rap1 in inside-out integrin signaling (Retta et al., 2006). 1D). These cells are in tight cohesion with one another and with the underlying matrix, forming a semipermeable barrier against the pressurized bloodstream. Integrin ligation also leads to Src activation and this has divergent downstream consequences, often involving RhoGTPases (Huveneers and Danen, 2009). In addition to its role in stabilizing cell–cell junctions through dephosphorylation of junctional components, PTPμ might also recruit regulatory proteins to sites of cell–cell adhesion (Sallee et al., 2006). These shared effectors include kinases, adaptor proteins and cytoskeletal components. (C) Lateral coupling of adhesion receptors allows for signaling in the absence of extracellular matrix or cell–cell adhesion. A number of congenital and acquired disease states have been associated with integrins, and small- molecule integrin inhibitors have been approved for treatment of benign hematologic diseases. Abbreviations: CDH2, cadherin-2; LRP, low-density lipoprotein receptor. Rac is required for epithelial wound healing and promotes cell migration when activated at cell–matrix contact sites, but promotes cell–cell adhesion and formation of adherens junctions when activated at cell–cell junctions (Van Aelst and Symons, 2002; Liu et al., 2010). Requirements for adhesion and motility, Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension, Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength, Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions, The challenges of abundance: epithelial junctions and small GTPase signalling, A cytokinesis furrow is positioned by two consecutive signals, Regulation of cell adhesion by protein-tyrosine phosphatases. Rac, Rho and Cdc42 are not the only GTPases functioning in the signaling network that connects integrins and cadherins. Involvement of the alphaV integrins, Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways, VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells, Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts, Protein tyrosine phosphatases and signalling, Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells, Collective chemotaxis requires contact-dependent cell polarity, Plakoglobin regulates cell motility through Rho- and fibronectin-dependent Src signaling, Physical forces during collective cell migration, The vimentin cytoskeleton regulates focal contact size and adhesion of endothelial cells subjected to shear stress, A mechanosensory complex that mediates the endothelial cell response to fluid shear stress, Role of Rho family GTPases in epithelial morphogenesis, Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures, Transforming growth factor beta regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells, Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo, Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension, Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases, Role of integrins in regulating epidermal adhesion, growth and differentiation, FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly, p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho, Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions, Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion, Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion, Plakoglobin suppresses keratinocyte motility through both cell-cell adhesion-dependent and -independent mechanisms, alpha-Catenin as a tension transducer that induces adherens junction development, Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells, Plakoglobin and beta-catenin: protein interactions, regulation and biological roles, Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation, Lamins in the nuclear interior − life outside the lamina, Mechanisms of regulation and diversification of deubiquitylating enzyme function, Adhesive crosstalk – re-evaluation of concepts and the case for adhesive networks, Adhesive networks in mechanotransduction and multicellular processes, A Travelling Fellowship unravels 3D chromatin structure, Gastruloids, pescoids, caveoids, surfoids…. 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